Freiburg scientists discover a new pro-survival receptor module on human tumor B cells

Many tumor diseases are caused by an overexpression and deregulation of signaling proteins promoting the prolonged survival and continuous growth of cells. This is also the case for the most frequent hematological tumors in humans namely B cell leukemia or lymphomas also called blood cancer. These tumors often employ the signaling pathways of the B cell antigen receptor (BCR) and its coreceptor CD19 for their extensive growth and metabolic fitness. How exactly these tumors combine BCR and coreceptor signaling was so far unknown.

The research team led by Prof. Dr. Michael Reth and including Dr. Jianying Yang and Dr. Xiaoxui He has now discovered a new pro-survival receptor module on the surface of the human Burkitt lymphoma B cell line Ramos. The scientists have published these findings in the EMBO Journal.

The full article can be found on the Bioss website.

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