Professor Kurt Hilse verstarb bereits am 13. Dezember im Alter von 95 Jahren.

Kurt Hilse wurde 1928 in Waldenburg geboren. Aufgrund der Kriegswirren nahm er erst 1942 sein Studium der Chemie an der Ludwig-Maximilians-Universität München auf. Zur Diplom- und Doktorarbeit ging er an das Max-Planck-Institut für Biochemie unter Adolf Butenandt, wo er in der Arbeitsgruppe Braunitzer maßgeblich an der Sequenzierung des Humanhämoglobins beteiligt war. Nach seiner Promotion arbeitete er ab 1958 als postdoctoral fellow am Oak Ridge Laboratory in Tennessee, USA. Als Molekularbiologe der ersten Stunde forschte er am genetischen Code und half bei dessen Aufklärung. Seine Forschung auf dem Gebiet der Globin-Allele und der Hämoglobinsynthese führten ihn schließlich 1969 nach Freiburg an das frisch gegründete Institut für Biologie III. Nach Habilitation 1972 und Ernennung zum Professor unserer Fakultät galt sein Interesse den Regulationsmechanismen der Proteinbiosynthese. Bis zu seiner Emeritierung im April 1993 war er einer der prägenden Forscher am Institut.

In stiller Trauer,

Das Kollegium des Instituts für Biologie 3

(c) Netzwerk Südbaden

The work of the Lab of Ralf Baumeister was recently the topic in two different articles in local newspapers:

First, Kathrin Ermert from Netzwerk Südbaden looked into the century old question of why organisms age. She visited the laboratory for this purpose and had a conversation with Ralf Baumeister. The article can be downloaded from our Homepage. We thank Netzwerk Südbaden allowing us to do so.

Link to the article on our BioCloud

Second, Badische Zeitung reported about a recent work of Wenjing Qi and other people from our faculty on heat adaptation of organisms. The article can be found here.

Artikel in der badischen Zeitung

They are referring to an original announcement from the university, which can be found at the following link.

Original article from the University

Original publication:

Xu, F, Li, R., von Gromoff, E. D., Drepper, F., Knapp, B., Warscheid, B., Baumeister, R., Qi, W.: Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans, in: Nature Communications 14 (2023). DOI: https://doi.org/10.1038/s41467-023-39882-8

Prof. Dr. Susana Minguet is an accomplished scientist and immunologist whose research focuses on the activation of T- and B-lymphocytes. Her work aims to enhance the understanding of T-cell activation and develop translational and synthetic applications to improve T-cell immunotherapies against cancer. With an impressive academic background and extensive experience in various research institutions, Prof. Dr. Minguet has made significant contributions to the field of immunology and we are very happy to welcome her now officially to our Institute.

Career Highlights:

Prof. Dr. Minguet obtained her Ph.D. in Biochemistry and Molecular Biology from the Universidad Autónoma de Madrid (UAM) in Spain, following a diploma degree in Chemistry (Biochemistry and Molecular Biology) from the same institution.

She pursued postdoctoral research at the Max Planck Institute for Immunobiology and Epigenetics in Freiburg from 2003 to 2007. Prof. Dr. Minguet worked then as a Ramón & Cajal Fellow at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) in Madrid, Spain, from 2008 to 2011. Since 2011, she has served as a group leader in Immunology at the Faculty of Biology, University of Freiburg, where she oversees cutting-edge research, teaches and mentors young scientists. Prof. Dr. Minguet became a member of the Center of Chronic Immunodeficiency (CCI) at the University Clinics Freiburg in 2016. Prof. Dr. Minguet has also been affiliated with the Cluster of excellence BIOSS, Centre for Biological Signalling Studies since 2017.

In 2018, she obtained her habilitation in Immunology from the Faculty of Biology at the University of Freiburg, recognizing her as an expert in the field. Since 2019, Prof. Dr. Minguet has been a member of the Cluster of Excellence CIBSS – Centre for Integrative Biological Signalling Studies, where she contributes to interdisciplinary research collaborations.

Selected Publications:

Prof. Dr. Minguet has published numerous highly regarded articles in reputable scientific journals. Some of her notable publications include:

• Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S. Minguet, S. (2023). Breast Cancer Stem Cell-Derived Tumors Escape from gd T-cell Immunosurveillance In Vivo by Modulating gd T-cell Ligands. Cancer Immunol Res. 2023 May 4:OF1-OF20. doi: 10.1158/2326-6066.CIR-22-0296.
• Hartl, F. A., Beck-Garcìa, E., Woessner, N. M., Flachsmann, L. J., Cárdenas, R. M. V., Brandl, S. M., . . . Minguet, S. (2020). Noncanonical binding of Lck to CD3e promotes TCR signaling and CAR function. Nature Immunology 21(8), 902-913; doi:10.1038/s41590-020-0732-3
• Minguet, S.*, Klaesener, K., Schaffer, A. M., Fiala, G. J., Osteso-Ibanez, T., Raute, K., . . . Del Pozo, M. A. (2017). Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nature Immunology 18(10), 1150-1159; doi:10.1038/ni.3813; *corresponding author
• Schoenle, A., Hartl, F. A., Mentzel, J., Nöltner, T., Rauch, K. S., Prestipino, A., . . ., Minguet, S.* & Zeiser, R.* (2016). Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells. Blood 127(15), 1930-1939; doi:10.1182/blood-2015-09-672428; *co-authorship
• Swamy, M., Beck-Garcia, K., Beck-Garcia, E., Hartl, F. A., Morath, A., Yousefi, O. S., . . ., Minguet, S.* & Schamel, W. W.* (2016). A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity 44(5), 1091-1101; doi:10.1016/j.immuni.2016.04.011; *co-authorship
• Fiala, G. J., Janowska, I., Prutek, F., Hobeika, E., Satapathy, A., Sprenger, A., . . ., Minguet, S.* & Schamel, W. W.* (2015). Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. Journal of Experimental Medicine 212(10), 1693-1708; doi:10.1084/jem.20141271; *co-authorship
• Goetz, J. G.*, Minguet, S.*, Navarro-Lérida, I., Lazcano, J. J., Samaniego, R., Calvo, E., . . . Del Pozo, M. A. (2011). Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell 146(1), 148-163; doi:10.1016/j.cell.2011.05.040; *co-authorship